Search results for "MHC class II"

showing 10 items of 82 documents

Linking species habitat and past palaeoclimatic events to evolution of the teleost innate immune system

2017

Host-intrinsic factors as well as environmental changes are known to be strong evolutionary drivers defining the genetic foundation of immunity. Using a novel set of teleost genomes and a time-calibrated phylogeny, we here investigate the family of Toll-like receptor ( TLR ) genes and address the underlying evolutionary processes shaping the diversity of the first-line defence. Our findings reveal remarkable flexibility within the evolutionary design of teleost innate immunity characterized by prominent TLR gene losses and expansions. In the order of Gadiformes, expansions correlate with the loss of major histocompatibility complex class II ( MHCII ) and diversifying selection analyses sup…

0106 biological sciences0301 basic medicine1001198Evolutionpast climatic changeLineage (evolution)ClimateGenes MHC Class II199010603 evolutionary biology01 natural sciencesGenomeGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesImmune systemPhylogeneticsAnimalsGeneAtlantic Oceaninnate immunityEcosystemPhylogenyGeneral Environmental ScienceInnate immune systemadaptive evolutionGeneral Immunology and MicrobiologybiologyEcologyGadiformesToll-Like ReceptorsFishes70General Medicinegene lossbiology.organism_classificationBiological EvolutionImmunity InnateEvolvability030104 developmental biologygene expansionEvolutionary biologyImmune SystemGeneral Agricultural and Biological SciencesResearch Article
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Successive Losses of Central Immune Genes Characterize the Gadiformes' Alternate Immunity.

2016

Great genetic variability among teleost immunomes, with gene losses and expansions of central adaptive and innate components, has been discovered through genome sequencing over the last few years. Here, we demonstrate that the innate Myxovirus resistance gene (Mx) is lost from the ancestor of Gadiformes and the closely related Stylephorus chordatus, thus predating the loss of Major Histocompatibility Complex class II (MHCII) in Gadiformes. Although the functional implication of Mx loss is still unknown, we demonstrate that this loss is one of several ancient events appearing in successive order throughout the evolution of teleost immunity. In particular, we find that the loss of Toll-like r…

0106 biological sciences0301 basic medicineFish ProteinsLineage (genetic)LetterGenes MHC Class IIZoologyParacanthopterygiiadaptationteleosts010603 evolutionary biology01 natural sciencesEvolution Molecular03 medical and health sciencesOrthomyxoviridae InfectionsPhylogeneticsGeneticsAnimalsGenetic variabilityGeneinnate immunityEcology Evolution Behavior and SystematicsInnate immune systemPolymorphism GeneticbiologyGadiformesadaptive immunitygene lossAcquired immune systembiology.organism_classificationGadiformesToll-Like Receptor 5030104 developmental biologyEvolutionary biologyMyxovirus resistance (Mx)Gene DeletionGenome biology and evolution
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Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.

2017

WOS: 000397335400001

0106 biological sciences0301 basic medicineGene FlowGenotypeLocal adaptationPopulationGenes MHC Class II010603 evolutionary biology01 natural sciencesIntraspecific competitionGene flowMHC GenesBirds03 medical and health sciences[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisAnimals[ SDV.IMM ] Life Sciences [q-bio]/Immunology14. Life underwaterSelection GeneticeducationEcology Evolution Behavior and SystematicsAllelic diversity ; Local adaptation ; MHC genes ; Pathogen-mediated balancing selection ; Greater flamingosAllelesLocal adaptationeducation.field_of_studyGenetic diversitybiologyHistocompatibility Antigens Class IIGenetic VariationAllelic diversityMHC genesExonsbiology.organism_classificationPathogen-mediated balancing selection030104 developmental biologyEvolutionary biologyGreater flamingosBiological dispersal[SDV.IMM]Life Sciences [q-bio]/ImmunologyGreater flamingoAdaptation[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/SymbiosisResearch Article
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Sex Alters the MHC Class I HLA-A Association With Polyglandular Autoimmunity.

2018

Abstract Context The major histocompatibility complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA). Objective To evaluate the impact of sex on human leukocyte antigen (HLA) association with PGA for the first time. Design Cross-sectional immunogenetic study. Setting Academic tertiary referral Orphan Disease Center for PGA (ORPHA 282196) and immunogenetics laboratory. Subjects Patients (158) with coexistent type 1 diabetes and autoimmune thyroid disease (adult type 3 PGA, ORPHA 227982) and 479 unrelated healthy controls. Interventions All 637 white subjects were typed for HLA-A, -B, -DRB1, -DQA1, and -DQB1 alleles at a two-field level. Main Outcome Measure…

0301 basic medicineAdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismClinical Biochemistry030209 endocrinology & metabolismContext (language use)Human leukocyte antigenMajor histocompatibility complexmedicine.disease_causeBiochemistryAutoimmunity03 medical and health sciences0302 clinical medicineEndocrinologySex FactorsGene FrequencyInternal medicineMHC class ImedicineHumansGenetic Predisposition to DiseasePolyendocrinopathies AutoimmuneType 1 diabetesMHC class IIbiologyHLA-A Antigensbusiness.industryHistocompatibility TestingBiochemistry (medical)Histocompatibility Antigens Class IMiddle Agedmedicine.diseasePrognosisHLA-A030104 developmental biologyEndocrinologyCross-Sectional StudiesDiabetes Mellitus Type 1HaplotypesCase-Control Studiesbiology.proteinFemalebusinessBiomarkersFollow-Up StudiesThe Journal of clinical endocrinology and metabolism
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Mast cells within cellular networks

2018

Mast cells are highly versatile in terms of their mode of activation by a host of stimuli and their ability to flexibly release a plethora of biologically highly active mediators. Within the immune system, mast cells can best be designated as an active nexus interlinking innate and adaptive immunity. Here we try to draw an arc from initiation of acute inflammatory reactions to microbial pathogens to development of adaptive immunity and allergies. This multifaceted nature of mast cells is made possible by interaction with multiple cell types of immunologic and nonimmunologic origin. Examples for the former include neutrophils, eosinophils, T cells, and professional antigen-presenting cells. …

0301 basic medicineCell typeSensory Receptor CellsNeutrophilsT-LymphocytesImmunologyAntigen-Presenting CellsCell CommunicationAdaptive Immunity03 medical and health sciences0302 clinical medicineImmune systemmedicineAnimalsHumansImmunology and AllergyMast CellsAntigen-presenting cellToll-like receptorMHC class IIbiologyAcquired immune systemMast cellAsthmaImmunity InnateEosinophilsCrosstalk (biology)030104 developmental biologymedicine.anatomical_structureImmunologybiology.protein030215 immunologyJournal of Allergy and Clinical Immunology
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Mortality in COVID-19 disease patients: Correlating Association of Major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (S…

2020

Highlights • In addition to ethnicity, socio-economic factors, prior vaccinations and exposure to other coronaviruses, other factors need to be considered to explain geographical and regional variations in susceptibility, severity of clinical expression of COVID-19 disease and outcomes. • Differences in peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles frequent in individuals with African, Asian or Caucasian descent could be identified. • Single mutations in the wildtype of SARS-CoV-2, the so called B strain or L strain impact on MHC presentation • Most likely there is selective pressure from MHC class II alleles in regard to binding of the ORF8 (L84S) v…

0301 basic medicinecross-reactivityMHC bindingPeptide bindingmedicine.disease_causeAutoimmunity0302 clinical medicine030212 general & internal medicineMutationepitopeautoimmunityGeneral MedicineHLAEuropeviral variantsInfectious DiseasesCoronavirus InfectionsPeptides ; COVID-19 ; Disease association ; Cross-reactivity ; MHC ; T-cells ; Autoimmunity ; Epitope ; Cytokines ; Viral variants ; HLA ; SARS ; SARS-CoV-2 ; MHC bindingMicrobiology (medical)Asia030106 microbiologyPneumonia ViralHuman leukocyte antigenBiologyMajor histocompatibility complexArticlelcsh:Infectious and parasitic diseases03 medical and health sciencesBetacoronavirusMHC class ImedicineHumanslcsh:RC109-216AllelePandemicsAllelesSARSMHC class IISARS-CoV-2T-cellsdisease associationHistocompatibility Antigens Class IHistocompatibility Antigens Class IICOVID-19cytokinesImmunologyAfricabiology.proteinpeptidesMHCInternational Journal of Infectious Diseases
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Loss of interferon-gamma inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as we…

2008

Summary Background  Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair the cellular immune response and promote tumour evasion from immune surveillance. So far, studies analysing the MHC class II expression levels in head and neck cancer have been limited. Objectives  Therefore, we investigated the constitutive and interferon (IFN)-γ-regulated expression profiles of MHC class II antigen processing machinery (APM) in various head and neck cancer cell lines and also analysed the MHC class II expression in head and neck cancer lesions. Methods  Using immunohistochemistry, flow cytometry, and reverse transcriptase-polymerase chain reaction analyses we in…

AdultCD4-Positive T-LymphocytesMaleTranscription Geneticchemical and pharmacologic phenomenaDermatologyMajor histocompatibility complexMHC class II antigenInterferon-gammaAntigenCell Line TumorMHC class ICIITAmedicineHumansRNA Processing Post-TranscriptionalAgedMHC class IIAntigen PresentationbiologyAntigen processingReverse Transcriptase Polymerase Chain ReactionHistocompatibility Antigens Class IICancerMiddle Agedmedicine.diseaseFlow CytometryImmunohistochemistryHead and Neck Neoplasmsbiology.proteinCancer researchCarcinoma Squamous CellFemale
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C4BQ0: a genetic marker of familial HCV-related liver cirrhosis

2004

Source Department of Medicine and Pneumology, V Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy. lindpas@yahoo.it Abstract BACKGROUND AND METHODS: Host may have a role in the evolution of chronic HCV liver disease. We performed two cross-sectional prospective studies to evaluate the prevalence of cirrhosis in first degree relatives of patients with cirrhosis and the role of two major histocompatibility complex class III alleles BF and C4 versus HCV as risk factors for familial clustering. FINDINGS: Ninety-three (18.6%) of 500 patients with cirrhosis had at least one cirrhotic first degree relative as compared to 13 (2.6%) of 500 controls, (OR 7.38; CI 4.21-12.9). C4BQ0 was signifi…

AdultGenetic MarkersLiver Cirrhosismedicine.medical_specialtyCirrhosisAdolescentFamilial clusteringFamilial clusteringGastroenterologyLiver cirrhosiC4BQ0Liver diseaseInternal medicineHCV diffusionComplement C4bPrevalencemedicineHumansProspective StudiesAlleleFamily historyFirst-degree relativesMHC class III allelesChildProspective cohort studyAllelesAgedAged 80 and overHepatologybusiness.industryGastroenterologyHepatitis C ChronicMiddle Agedmedicine.diseaseCross-Sectional StudiesGenetic markerbusinessC4BQ0; Familial clustering; HCV diffusion; Liver cirrhosis; MHC class III allelesDigestive and Liver Disease
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The influence of major histocompatibility complex class II genes and T-cell Vbeta repertoire on response to immunization with HBsAg.

1998

Nonresponsiveness to HBsAg vaccination is observed in 5-10% of vaccine recipients and is possibly caused by a defect in the T helper cell compartment. The immune response to HBsAg is influenced by genes of the major histocompatibility complex. We have investigated MHC class I and class II antigens in 53 adult responders and 73 nonresponders. Results obtained in this first study were tested in a second study with 56 responders and 62 nonresponders from an infant vaccination trial. In addition, the peripheral Vbeta-chain T-cell receptor repertoire was investigated using monoclonal antibodies and flow-cytometry in 26 adult responders and 38 nonresponders. As previously reported, nonresponsiven…

AdultHBsAgT cellReceptors Antigen T-Cell alpha-betaImmunologyGenes MHC Class IIMajor histocompatibility complexCohort StudiesImmune systemGene FrequencyMHC class ImedicineImmunology and AllergyHumansHepatitis B VaccinesAllelesDiphtheria-Tetanus-Pertussis VaccineHepatitis B Surface AntigensbiologyT-cell receptorInfantGeneral MedicineT helper cellHLA-DR AntigensVirologyVaccinationmedicine.anatomical_structureImmunologybiology.proteinImmunizationHLA-DRB1 ChainsHuman immunology
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HLA-DRB1*1301 AND *1302 protect against chronic hepatitis B

1997

Abstract Background/Aims: The outcome of acute hepatitis B infection may be influenced by host factors like the major histocompatibility complex (MHC). We have investigated MHC class I and class II antigens in patients with chronic hepatitis B compared to a healthy control population. To confirm the findings of this first study we performed a second study in a group of subjects who had spontaneously recovered from acute hepatitis B infection. Methods: Frequencies of MHC class I and class II antigens were analyzed in patients with chronic hepatitis B virus infection and in control subjects. MHC class I typing was done by standard microlymphocytotoxicity assays. DRB1 and DQA1 genotypes were d…

AdultHepatitis B virusRemission SpontaneousPopulationEnzyme-Linked Immunosorbent AssayMajor histocompatibility complexmedicine.disease_causePolymerase Chain ReactionHLA-DQ alpha-ChainsVirusHLA-DQ AntigensMHC class ImedicineHumansSerologic TestsProspective StudiesHepatitis B AntibodieseducationHLA-DRB1AllelesHepatitis B viruseducation.field_of_studyMHC class IIHepatitis B Surface AntigensHepatologybiologyHLA-DR AntigensHepatitis BVirologyChronic infectionImmunoglobulin GChronic DiseaseDNA ViralImmunologybiology.proteinHLA-DRB1 ChainsJournal of Hepatology
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